The Potent Cytotoxic and Oxidative Effects of β-2 Selective ICI-118,551 on Breast Adenocarcinoma Cell Lines with Different Aggressiveness

Objective: Beta-blockers are a group of drugs used in the treatment cardiovascular ailments. On other hand, potential anticancer effects these have become increasingly important recent two decades. In this paper, beta-1 selective esmolol, beta-2 ICI-118,551 and non-selective nadolol on breast cancer cell lines with different aggressiveness were investigated for first time. Methods: A standard spectrophotometric MTT assay was to determine viability. Catalase activities malondialdehyde levels measured spectrophotometrically based reduction absorbance resulted from hydrogen peroxide decomposition formation thiobarbituric acid- product, respectively. Results: It found that most effective one among blockers against MCF-7 MDA-MB-231 lines. Additionally, it seen 50-150 µM 48 hours significantly changed catalase both favour radical production. Conclusion: The obtained results showed adrenergic receptor specific antagonism plays significant role beta-blocker induced death. outstanding suppression concomitant increases appear contribute potent cytotoxic effect adenocarcinoma. Consequently, can be clearly interpreted may valuable option cancer.